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We work at the intersection of computational neuroscience and artificial intelligence

We are interested in understanding behavior in computational terms and in reverse-engineering the algorithms of the brain.

Research Directions

We develop artificial intelligence tools for behavioral and neural data analysis, and conversely try to learn from the brain to solve challenging artificial intelligence problems.

Artificial Intelligence for Behavior Analysis

We strive to develop tools for the analysis of animal behavior. Behavior is a complex reflection of an animal's goals, state and character. Thus, accurately measuring behavior is crucial for advancing basic neuroscience, as well as the study of various neural and psychiatric disorders. However, measuring behavior (from video) is also a challenging computer vision and artificial intelligence problem.

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DeepLabCut
DLC2action
LLaVAction

Embodied AI & Musculoskeletal Control

Watching an expert athlete makes it obvious that brains have mastered the elegant control of our bodies — an astonishing feat given slow biological hardware and the sensory and motor latencies that constantly impede control. Understanding how the brain produces skilled movement is one of the central questions in neuroscience, and building agents that move as capably is one of the hardest open problems in AI. We work on both at once, using reinforcement learning, control theory, and curriculum learning to train biomechanically realistic, muscle-actuated models of the body.

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DMAP
Lattice
MyoChallenge 2022

Task-Driven and Data-Driven Models of Proprioception as well as Sensorimotor Processing

We develop normative theories and models for sensorimotor transformations and learning. Work in the past decade has demonstrated that networks trained on object-recognition tasks provide excellent models for the visual system. Yet, for sensorimotor circuits this fruitful approach is less explored, perhaps due to the lack of datasets like ImageNet.

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proprioceptive illusions
task-driven primate

Latest Research

Breakthroughs and discoveries from our lab

Towards Embodied AI with MuscleMimic: Unlocking full-body musculoskeletal motor learning at scale
Preprint2026
Towards Embodied AI with MuscleMimic: Unlocking full-body musculoskeletal motor learning at scale

C Li*, C Wang*, B Ziliotto, M Simos, J Kovecses, G Durandau, A Mathis

Arnold: a generalist muscle transformer policy
arXiv preprint2025
Arnold: a generalist muscle transformer policy

AS Chiappa, B An, M Simos, C Li, A Mathis

EPFL-Smart-Kitchen: An Ego-Exo Multi-Modal Dataset for Challenging Action and Motion Understanding in Video-Language Models
NeurIPS 2025 Datasets and Benchmarks Track2025
EPFL-Smart-Kitchen: An Ego-Exo Multi-Modal Dataset for Challenging Action and Motion Understanding in Video-Language Models

A Bonnetto*, H Qi*, F Leong, M Tashkovska, M Rad, S Shokur, F Hummel, S Micera, M Pollefeys, A Mathis

MammAlps: A multi-view video behavior monitoring dataset of wild mammals in the Swiss Alps
CVPR (highlight)2025
MammAlps: A multi-view video behavior monitoring dataset of wild mammals in the Swiss Alps

V Gabeff, H Qi, B Flaherty, G Sumbül, A Mathis*, D Tuia*

Open Science & Community Impact

We are passionate about open-source code and making our tools broadly accessible to the scientific community.

40+
Publications
20+
Open sourced tools
NeurIPS Winners

Join Our Team

We are actively looking for undergraduate, master's, and PhD students with interests in behavioral analysis and modeling sensorimotor learning. We also regularly recruit postdoctoral fellows.

Supported By

We gratefully thank our funders who keep the magic alive

Simons Collaboration on Ecological NeuroscienceSwiss National Science FoundationBoehringer Ingelheim FondsEPFL Center for ImagingMicrosoftChan Zuckerberg InitiativeKavli Foundation